Informatics Publishing Limited

P. G. Bhange ¹, A. P. Mehere ², T. P. Nimbekar ¹, P. P. Katolkar ¹

Affiliations
1 Manoharbhai Patel Institute of Pharmacy (B. Pharma), Gondia (MS) 441614, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur (MS), IN

Abstract

Dispersible tablet of amoxicillin sodium and cloxacillin sodium were prepared by employing different superdisintegrants and disintegrants such as microcrystalline cellulose and sodium starch glycolate, crosscarmellose sodium, crosspovidon, in different concentrations by direct compression method, formulation were evaluated for the standard of dispersible tablets and were compare with marketed product. The formulated tablets fulfilled all official (I.P.) requirement of dispersible tablet and give fast dissolution of amoxicillin plus cloxacillin sodium when compared to conventional marketed tablet of same drug. Study reveals that Dispersible tablet formulated by osscarmellose sodium employing gave fastest dissolution of amoxicillin plus cloxacillin sodium.

Keywords

Dispersible Tablet, Direct Compression, Amoxicillin And Cloxacillin Sodium, Sodium Starch Glycolate, Carmellose Sodium, Crospovidon, Superdisintegrants.

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Swapna S. Kulkarni ¹, A. P. Mehere ², Priyank A. Shenoy ¹

Affiliations
1 Alard College of Pharmacy, Sr.no 50, Marunje, Rajiv Gandhi Infotech Park, Pune-411057, Maharashtra, IN
2 Sharad Pawar College of Pharmacy, Wanadongari, Nagpur, Maharashtra, IN

Abstract

An amide derivative of P-aminobenzoic acid (PABA) has been synthesized from piperazine by initial conversion of PABA into its hydrochloride salt for protection of amino group from self-polymerization. The compound identity has been characterized by Melting point, Elemental Analysis, TLC, UV-Visible spectroscopy, IR spectroscopy and NMR spectroscopy. The antibacterial activity of the compound has been studied against E.coli, S.aureus, B.subtilis and P.aeruginosa using tetracycline as a standard. Antifungal activity of the compound has been studied against C.albicans and A.niger using clotrimazole as a standard. The synthesized compound has been found to possess significant antibacterial and antifungal activities as compared to the standard drugs used.

Keywords

Amide Derivative, PABA, Self-Polymerization, Antibacterial, Antifungal.

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